Kisspeptin

Scientific Overview

Kisspeptin refers to peptides encoded by KISS1 that activate the KISS1R receptor, also called GPR54. Research centers on how this signaling controls GnRH neurons and the reproductive endocrine axis.

Mechanism focus

Kisspeptin-KISS1R signaling is studied as an upstream input to hypothalamic GnRH release. Reviews cover receptor biology and reproductive neuroendocrinology rather than a single downstream pathway.

Research Use Cases

• GnRH neuron signaling models
• KISS1R receptor pharmacology
• Reproductive-axis research
• Comparison of kisspeptin peptide forms

Use-Case Study Notations

• Case-study notation: reviews describe kisspeptin/GPR54 signaling as a regulator of the reproductive endocrine axis.
• Case-study notation: experimental papers examine kisspeptin in relation to GnRH and luteinising-hormone physiology.
• This catalog page does not present fertility or other clinical outcome claims.

Selected Studies

1. 01 The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and ReproductionPubMed 35837314
2. 02 Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?PubMed 30205368
3. 03 The role of kisspeptin/GPR54 in the reproductive systemPubMed 21576407
4. 04 Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive healthPubMed 36262016
5. 05 Oestrogen, kisspeptin, GPR54 and the pre-ovulatory luteinising hormone surgePubMed 19207812

Related compounds

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