MOTS-c

Scientific Overview

MOTS-c is a peptide encoded in mitochondrial 12S rRNA. Research examines its proposed roles in metabolic homeostasis, muscle and fat metabolism, and mitochondrial-nuclear communication.

Mechanism focus

Preclinical studies explore AMPK-related metabolic signaling and cellular responses to metabolic stress. Human evidence is earlier-stage than the cell and animal literature.

Research Use Cases

• Mitochondrial-derived peptide assays
• Metabolic homeostasis models
• Cellular stress-signaling studies
• Comparison with other mitochondrial peptides

Use-Case Study Notations

• Case-study notation (preclinical): the original description linked MOTS-c to metabolic homeostasis in cell and mouse models.
• Case-study notation: later reviews discuss MOTS-c as a mitochondrial-derived peptide with metabolic research interest.
• This page does not present clinical outcome claims.

Selected Studies

1. 01 The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistancePubMed 25738459
2. 02 The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic StressPubMed 29983246
3. 03 Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltrationPubMed 38170165
4. 04 Mitochondrial-Derived Peptide MOTS-c Increases Adipose Thermogenic Activation to Promote Cold AdaptationPubMed 31109005
5. 05 MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitationPubMed 36761202

Related compounds

SS-31 · AOD-9604