Immune
KPV
α-MSH C-Terminal Tripeptide
Amino acid sequence
N-terminus →
01KLys
02PPro
03VVal
→ C
- Polar
- Hydrophobic
- Acidic
- Basic
- Linear
- 3 residues
Scientific Overview
KPV is the C-terminal tripeptide of α-melanocyte–stimulating hormone, studied for anti-inflammatory and barrier-protective effects, including PepT1-mediated intestinal uptake.
Mechanism focus
Melanocortin-related anti-inflammatory signaling with evidence for reduced NF-κB–linked cytokine programs; intestinal transport via PepT1 is a distinctive research feature.
Research Use Cases
- Intestinal inflammation and colitis models
- Cutaneous inflammation / wound immunomodulation
- Melanocortin peptide structure–activity studies
- Peptide transporter (PepT1) research
Use-Case Study Notations
- Case-study notation: PepT1-mediated KPV uptake was linked to reduced intestinal inflammation in experimental models.
- Case-study notation: classic α-MSH fragment work dissected anti-inflammatory contributions of the KPV motif.
- Tripeptide identity testing is straightforward by MS but formulation stability still matters.
Selected Studies
- 01 Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptidesPubMed 12750433
- 02 PepT1-mediated tripeptide KPV uptake reduces intestinal inflammationPubMed 18061177
- 03 alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signallingPubMed 15102092
- 04 alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugsPubMed 17934097
- 05 Are melanocortin peptides future therapeutics for cutaneous wound healing?PubMed 30661264
Related compounds
Research Use Only. This page is educational and intended for laboratory research context. Products are not for human consumption and are not intended to diagnose, treat, cure, or prevent any disease.